Likewise, if the condition you are trying to match on is just a protocol or port, without a path, feel free to use "is". You can also use "is" and include the full path of the process. In this example, our chrome rule would look like:
C:\Program Files\Chrome\chrome.exe
You can follow the same rule building logic for other events. For example, here is one for the FileCreate event. This way you can exclude certain processes from logging an event when they create a file.